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Report

Considerations for commercial plan sponsors evaluating specialty drug carve-out programs

23 March 2026

With the rise in specialty drug costs, plan sponsors are increasingly seeking to control prescription drug spending. One approach that has emerged in recent years is specialty pharmacy drug carve-out programs. In these arrangements, the plan sponsor contracts directly with a vendor to manage the specialty pharmacy benefit, which may include prescription drug fulfillment, prior authorization criteria development and reviews, and site-of-care management. These programs typically interact with the core services offered by the plan sponsor’s pharmacy benefit manager (PBM). AbbVie commissioned Milliman to prepare a white paper describing key considerations for plan sponsors as they evaluate specialty pharmacy carve-out options.

Key considerations discussed:

  • Specialty utilization contractual impacts: Carving out specialty management to a separate vendor will likely impact financial guarantees within existing PBM arrangements, and may be accompanied by a fee.
  • Vendor savings projections: Plan sponsors should carefully evaluate a range of factors that may influence the net financial impact.
  • Vendor and PBM Fees: While potential savings of 20% to 50% of specialty drug spend is significant, sponsors should assess a range of other financial considerations.
  • PBM contract considerations: Carving out specialty drug management may affect existing PBM network rates, rebates, and other financial guarantees.
  • Qualitative considerations: Plan sponsors need to evaluate factors such as member experience and non-medical drug switching, biosimilar adoption, drug coverage, and a disintegrated pharmacy benefit.

This report was commissioned by AbbVie.


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